A neurodevelopmental basis for BECTS: Evidence from structural MRI

HR Pardoe; AT Berg; JS Archer; RK Fulbright; GD Jackson

Journal article

A neurodevelopmental basis for BECTS: Evidence from structural MRI

HR Pardoe, AT Berg, JS Archer, RK Fulbright, GD Jackson

Epilepsy Research | ELSEVIER SCIENCE BV | Published : 2013

DOI: 10.1016/j.eplepsyres.2012.11.008

Abstract

Purpose: BECTS (benign epilepsy with centro-temporal spikes) is one of the most common childhood-onset epilepsy syndromes. We investigated quantitative evidence for brain morphological variation associated with BECTS to provide insights into the neuroanatomical basis of this disorder. Methods: Three independent BECTS groups were imaged at different stages: (a) near onset (. n=. 16, mean age 9.3. ±. 1.6 years), (b) ~9 years after onset (. n=. 9, mean age 15.8. ±. 2.3 years), and (c) ~15 years after onset (. n=. 10, mean age 22.7. ±. 2.7 years). Age-matched controls were imaged with each group. Whole brain T1-weighted MRI was acquired. Voxel-based morphometry (groups a-c) and cortical thicknes..

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University of Melbourne Researchers

Heath Pardoe Author

John Archer Author

Graeme Jackson Author

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Grants

Awarded by National Institutes of Health

Funding Acknowledgements

Study funding: National Institutes of Health (NS-R37-31146, PI AT Berg), National Health and Medical Research Council, Australia (project grant 318900), National Health and Medical Research Council Australia (program grant 400121), Victorian Life Sciences Computational Initiative, Australia (VR0056), Victorian Government's Operational Infrastructure Support Program, Australia.